Beilstein J. Org. Chem.2014,10, 613–621, doi:10.3762/bjoc.10.52
a sample of the Caribbean sponge Akacoralliphagum collected off the coast of San Salvador in the Bahamas. The structures of the new compounds were elucidated on the basis of mass spectrometric and NMR spectroscopic analysis. Compounds 1–4 are derivatives of siphonodictyal E (9). Siphonodictyal E4
(4) exhibited mild antiproliferation activity against L929 mouse fibroblast, KB-31 epidermoid carcinoma, and MCF-7 breast cancer cell lines, while siphondictyal E3 (3) and cyclosiphonodictyol A (5) showed moderate activity against Gram-positive bacteria.
Keywords: Akacoralliphagum; bioassay
; natural products; NMR; sesquiterpene hydroquinone; structure elucidation; Introduction
Akacoralliphagum (Siphonodictyon coralliphagum) is known to have four distinct morphological forms: forma typica, f. tubulosa, f. obruta, and f. incrustans [1]. This sponge has the ability to burrow into live coral
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Graphical Abstract
Figure 1:
Structures of the new compounds siphonodictyals E1–E4 (1–4) and cyclosiphonodictyol A (5) isolated ...